Cause of Spastic Paralysis There are many different causes of Spastic Paralysis and each may affect a person different the causes include: · Spastic Paralysis can be caused by an infection called Meningitis that can be formed after birth. · Caused by nerve damage or nerve disease that affects the central nervous system. · Encephalitis is an inflammatory disease that can also cause it. · You can become paralysed when your spinal cord inflames and the nerve cells get compressed with causes not much oxygen to get to your nerves. When this happens the nerve cells can die, which causes the brains messages to not come through to the various parts of your body.